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In a study in adults, there was no difference between prilocaine and articaine in providing successful anesthesia of mandibular pulpal and lingual soft tissue and of maxillary palatal soft tissue with buccal infiltration. When administered intravenously, the mean volume of distribution (for 60-kg person) at steady state for lidocaine and prilocaine were 90 L and 156 L, respectively. However, your doctor may have special instructions on the proper use and dose, depending on the reason you are using lidocaine and prilocaine. The mean (±SD) prilocaine Cmax was 106 (±45) ng/mL, ranging between 53 and 181 ng/mL. Very young children (less than 1 year of age) may be especially sensitive to the effects of lidocaine and prilocaine.

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