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 Brand name: aciphex
Generic name: Rabeprazole, Pariet, Rablet
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The adverse reactions reported without regard to relationship to Aciphex that occurred in ≥ 2% of 111 patients were headache (9. Most patients received either 10 mg, 20 mg or 40 mg/day of Aciphex. The study was designed to provide at least 80% power to exclude a difference of at least 10% between Aciphex and omeprazole, assuming four-week healing response rates of 93% for both groups. Aciphex, known chemically as rabeprazole sodium, belongs to a class of drugs known as proton pump inhibitors designed to suppress production of stomach acid that can burn and damage the esophagus, a condition known as gastroesophageal reflux disease. Mean reductions from baseline in daily antacid dose were statistically significant for all Aciphex groups when compared to placebo at both Weeks 4 and 8 (p≤0. Normalization of 24-hour intraesophageal acid exposure was correlated to gastric pH>4 for at least 35% of the 24-hour period; this level was achieved in 90% of subjects receiving Aciphex 20 mg and in 100% of subjects receiving Aciphex 40 mg.

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